Renal amyloidosis causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]

The exact cause of renal amyloidiosis has not been identified. Most commonly causes of majority of the cases in renal amyloidosis idiopathic. Other causes include amyloidosis secondary to diseases such as tuberculosis, familial Mediterranean fever, rheumatoid arthritis, multiple myeloma or amyloidic mutations of transthyretin and fibrinogen protein.

In renal amyloidosis, most common causes include:^[1]

• Idiopathic ( Primary (AL) amyloidosis )
• Amyloidosis secondary to:
  • TB
  • Familial mediterranean fever (FMF)
  • Rheumatoid arthritis (RA)
  • Multiple myeloma

In renal amyloidosis, less common causes include:^[2]

• .Hereditary amyloidosis due to amyloidogenic mutations:
  • Transthyretin (TTR) (most common inherited mutation)
  • Fibrinogen
  • Apolipoprotein A1
  • Apolipoprotein A2
  • Lysozyme
  • Gelsolin genes

Template:WH Template:WS