Health Dictionary Find a Doctor

Renal oncocytoma biopsy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]

Overview

On biopsy, renal oncocytoma is characterized by oncocytes and large eosinophilic cells.

Biopsy

On biopsy, renal oncocytoma is characterized by oncocytes and large eosinophilic cells.
Biopsy is insufficient to distinguish renal oncocytoma from renal cell carcinoma, therefore immunostaining may be required.^[1]
Immunohistochemical profile^[2]

Cytokeratin AE1/AE3 +
Vimentin –
Epithelial membrane antigen +
CD10+/-
CK7 +/- parcellaire
CK20 –
CK19 –
AMACR (Racemase) –
S100 +
CD117 +
Cadherin-E +
TFE3 –
CAM5.2 +

References

↑ Liu J, Fanning CV (2001). “Can renal oncocytomas be distinguished from renal cell carcinoma on fine-needle aspiration specimens? A study of conventional smears in conjunction with ancillary studies”. Cancer. 93 (6): 390–7. PMID 11748579.
↑ [Renal Neoplasms: An Update on Immunohistochemical and Histochemical Features http://www.dako.com/08066_12may10_webchapter26.pdf]

Template:WH Template:WS

Terms and Conditions

© 2026 MyEClinic – IFTM Institut für Telematik in der Medizin GmbH