Riedel's thyroiditis medical therapy
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]
Overview
Pharmacologic medical therapies for Riedel’s thyroiditis include corticosteroids, tamoxifen, and mycophenolate mofetil.
Medical Therapy
- Pharmacologic medical therapies for Riedel’s thyroiditis include corticosteroids and tamoxifen.[1][2][3][4][5][6]
- Mycophenolate mofetil is also used in combination with corticosteroids.[7][8]
Treatment regimens for Riedel’s thyroiditis
The effectiveness of therapy and dosages for Riedel’s thyroiditis have not yet been assessed completely. As a result, the exact dosage regimens and duration of therapy cannot be defined. The current recommendations are based on the clinical manifestations, associated conditions, and the response to treatment.
- Preferred regimen (1): Prednisone 15-60mg PO q24h for 6 months to 2 years
- Preferred regimen (2): Prednisone 500 mg PO q24h for 6 months to 2 years
- Alternative regimen (1): Tamoxifen 10-20 mg PO q24h for 6 months to 2 years
- Alternative regimen (1): Mycophenolate mofetil 1 g PO q12h for 6 months to 2 years
References
- ↑ Zimmermann-Belsing T, Feldt-Rasmussen U (1994). “Riedel’s thyroiditis: an autoimmune or primary fibrotic disease?”. J. Intern. Med. 235 (3): 271–4. PMID 8120524.
- ↑ Vaidya B, Harris PE, Barrett P, Kendall-Taylor P (1997). “Corticosteroid therapy in Riedel’s thyroiditis”. Postgrad Med J. 73 (866): 817–9. PMC 2431527. PMID 9497955.
- ↑ Chopra D, Wool MS, Crosson A, Sawin CT (1978). “Riedel’s struma associated with subacute thyroiditis, hypothyroidism, and hypoparathyroidism”. J. Clin. Endocrinol. Metab. 46 (6): 869–71. doi:10.1210/jcem-46-6-869. PMID 263470.
- ↑ Bagnasco M, Passalacqua G, Pronzato C, Albano M, Torre G, Scordamaglia A (1995). “Fibrous invasive (Riedel’s) thyroiditis with critical response to steroid treatment”. J. Endocrinol. Invest. 18 (4): 305–7. doi:10.1007/BF03347818. PMID 7560814.
- ↑ Thomson JA, Jackson IM, Duguid WP (1968). “The effect of steroid therapy on Riedel’s thyroiditis”. Scott Med J. 13 (1): 13–6. doi:10.1177/003693306801300103. PMID 5694137.
- ↑ Dabelic N, Jukic T, Labar Z, Novosel SA, Matesa N, Kusic Z (2003). “Riedel’s thyroiditis treated with tamoxifen” (PDF). Croat. Med. J. 44 (2): 239–41. PMID 12698518.
- ↑ Levy JM, Hasney CP, Friedlander PL, Kandil E, Occhipinti EA, Kahn MJ (2010). “Combined mycophenolate mofetil and prednisone therapy in tamoxifen- and prednisone-resistant Reidel’s thyroiditis”. Thyroid. 20 (1): 105–7. doi:10.1089/thy.2009.0324. PMID 20067381.
- ↑ Fatourechi MM, Hay ID, McIver B, Sebo TJ, Fatourechi V (2011). “Invasive fibrous thyroiditis (Riedel thyroiditis): the Mayo Clinic experience, 1976-2008”. Thyroid. 21 (7): 765–72. doi:10.1089/thy.2010.0453. PMID 21568724.
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