Roseola laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omodamola Aje B.Sc, M.D. [2]

Overview

The diagnosis of roseola is made clinically. However, in atypical cases, the diagnosis can be made by both serologic and direct detection of HHV6 virus in the saliva of the patient. Expected results of diagnostic studies include antigen detection, PCR, and immunofluorescence.

Laboratory findings

The diagnosis of HHV-6A, HHV-6B, and HHV-7 infections is based on gene amplification (PCR). It allows for the detection and quantification of the viral genome, than on serology, which is mainly indicated in case of primary infection.^[1]
Neutropenia
Relative atypical lymphocytosis^[2]
Thrombocytopenia caused by bone marrow suppression.^[3]

References

↑ Agut H, Bonnafous P, Gautheret-Dejean A (2017). “Update on infections with human herpesviruses 6A, 6B, and 7”. Med Mal Infect. 47 (2): 83–91. doi:10.1016/j.medmal.2016.09.004. PMID 27773488.
↑ JURETIC M (1963). “Exanthema subitum a review of 243 cases”. Helv Paediatr Acta. 18: 80–95. PMID 13958107.
↑ Hashimoto H, Maruyama H, Fujimoto K, Sakakura T, Seishu S, Okuda N (2002). “Hematologic findings associated with thrombocytopenia during the acute phase of exanthem subitum confirmed by primary human herpesvirus-6 infection”. J Pediatr Hematol Oncol. 24 (3): 211–4. PMID 11990308.

[pmid27773488-1] Agut H, Bonnafous P, Gautheret-Dejean A (2017). “Update on infections with human herpesviruses 6A, 6B, and 7”. Med Mal Infect. 47 (2): 83–91. doi:10.1016/j.medmal.2016.09.004. PMID 27773488.

[pmid13958107-2] JURETIC M (1963). “Exanthema subitum a review of 243 cases”. Helv Paediatr Acta. 18: 80–95. PMID 13958107.

[pmid11990308-3] Hashimoto H, Maruyama H, Fujimoto K, Sakakura T, Seishu S, Okuda N (2002). “Hematologic findings associated with thrombocytopenia during the acute phase of exanthem subitum confirmed by primary human herpesvirus-6 infection”. J Pediatr Hematol Oncol. 24 (3): 211–4. PMID 11990308.

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