SLC9B2
Solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 is a protein that in humans is encoded by the SLC9B2 gene.[1]
Function
Sodium–hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain or the F1F0 mitochondrial ATPase into sodium gradients that drive other energy-requiring processes, transduce environmental signals into cell responses, or function in drug efflux.[2]
References
- ↑ “Entrez Gene: Solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2”.
- ↑ Xiang M, Feng M, Muend S, Rao R (November 2007). “A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension”. Proceedings of the National Academy of Sciences of the United States of America. 104 (47): 18677–81. doi:10.1073/pnas.0707120104. PMC 2141836. PMID 18000046.
Further reading
- Kondapalli KC, Kallay LM, Muszelik M, Rao R (October 2012). “Unconventional chemiosmotic coupling of NHA2, a mammalian Na+/H+ antiporter, to a plasma membrane H+ gradient”. The Journal of Biological Chemistry. 287 (43): 36239–50. doi:10.1074/jbc.M112.403550. PMC 3476291. PMID 22948142.
- Ha BG, Hong JM, Park JY, Ha MH, Kim TH, Cho JY, Ryoo HM, Choi JY, Shin HI, Chun SY, Kim SY, Park EK (July 2008). “Proteomic profile of osteoclast membrane proteins: identification of Na+/H+ exchanger domain containing 2 and its role in osteoclast fusion”. Proteomics. 8 (13): 2625–39. doi:10.1002/pmic.200701192. PMID 18600791.
- Huang X, Morse LR, Xu Y, Zahradka J, Sychrová H, Stashenko P, Fan F, Battaglino RA (December 2010). “Mutational analysis of NHAoc/NHA2 in Saccharomyces cerevisiae”. Biochimica et Biophysica Acta. 1800 (12): 1241–7. doi:10.1016/j.bbagen.2010.08.001. PMC 2967667. PMID 20713131.
- Fuster DG, Zhang J, Shi M, Bobulescu IA, Andersson S, Moe OW (August 2008). “Characterization of the sodium/hydrogen exchanger NHA2”. Journal of the American Society of Nephrology. 19 (8): 1547–56. doi:10.1681/ASN.2007111245. PMC 2488271. PMID 18508966.
- Kalsi G, Kuo PH, Aliev F, Alexander J, McMichael O, Patterson DG, Walsh D, Zhao Z, Schuckit M, Nurnberger J, Edenberg H, Kramer J, Hesselbrock V, Tischfield JA, Vladimirov V, Prescott CA, Dick DM, Kendler KS, Riley BP (June 2010). “A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts”. Human Molecular Genetics. 19 (12): 2497–506. doi:10.1093/hmg/ddq112. PMC 2876884. PMID 20332099.
- Battaglino RA, Pham L, Morse LR, Vokes M, Sharma A, Odgren PR, Yang M, Sasaki H, Stashenko P (January 2008). “NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts”. Bone. 42 (1): 180–92. doi:10.1016/j.bone.2007.09.046. PMC 3593247. PMID 17988971.
- Schushan M, Xiang M, Bogomiakov P, Padan E, Rao R, Ben-Tal N (March 2010). “Model-guided mutagenesis drives functional studies of human NHA2, implicated in hypertension”. Journal of Molecular Biology. 396 (5): 1181–96. doi:10.1016/j.jmb.2009.12.055. PMC 2824056. PMID 20053353.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
© 2026 MyEClinic – IFTM Institut für Telematik in der Medizin GmbH