Secondary adrenal insufficiency risk factors

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]

The most potent risk factor in the development of secondary adrenal insufficiency is infections, such as Tuberculosis. Other risk factors include genetic defects of adrenal gland, diabetes, and Vitiligo.

The following conditions increase the risk of adrenal insufficiency:

• Drugs
  • Chronic steroid therapy
  • Opiates
  • Antifungals- ketoconazole^[1]
• Genetic defects of adrenal gland
  • Congenital adrenal hyperplasia
• Other genetic defects
  • Combined pituitary hormone deficiency (CPHD)
• Diabetes
• Vitiligo
• Tuberculosis
• Amyloidosis
• AIDS-associated infections
• Cancer

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