Secondary amyloidosis history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]Shaghayegh Habibi, M.D.[3]

Symptoms of secondary amyloidosis may vary depending on the primary disorder and the affected organs. Secondary amyloidosis most commonly presents with kidney involvement and patients usually have a positive history of periorbital edema and frothy urine.

• Symptoms of secondary amyloidosis may vary depending on the primary disorder and the affected organs.^[1]
• Patients with secondary amyloidosis may have a positive history of inflammatory disorders such as familial mediterranean fever, rheumatoid arthritis, inflammatory bowel disease, and etc.
• Secondary amyloidosis most commonly presents with kidney involvement and patients usually have a positive history of periorbital edema and frothy urine.
• Abdominal mass, early satiety and other less common symptoms may be present in the case of other organ involvement.
• Other less common symptoms include:
  • Abdominal pain
  • Chronic diarrhea as a result of malabsorption
  • Numbness in fingers and toes