Secondary amyloidosis other diagnostic studies
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]
Overview
A tissue biopsy or fat aspirate should be done to confirm the presence or type of amyloid protein which is involved in the pathogenesis of the disease.
Other Diagnostic Studies
- A tissue biopsy or fat aspirate should be done to confirm the presence or type of amyloid protein which is involved in the pathogenesis of the disease.[1]
- To obtain a sample for histologic examination, multiple anatomical places have been used so far.
- In 1960s, gingival and mucosa biopsy were the anatomic places of choice, but they were now replaced by other more accessible places.
- Table below compares the recommended anatomical places.[2]
- It is of particular note that, a negative biopsy result for amyloid deposition would not exclude the diagnosis of amyloidosis, especially in the presence of high clinical suspicion.
| Test | Sensitivity | Specificity |
|---|---|---|
| Subcutaneous abdominal fat tissue aspiration | 57%–82% | 93%–100% |
| Rectal mucosa biopsy | 75%–85% | _ |
| Minor salivary gland biopsy | 83%–100% | _ |
References
- ↑ Mahmood S, Palladini G, Sanchorawala V, Wechalekar A (February 2014). “Update on treatment of light chain amyloidosis”. Haematologica. 99 (2): 209–21. doi:10.3324/haematol.2013.087619. PMC 3912950. PMID 24497558.
- ↑ Real de Asua, Diego; Galvan, Jose Maria; Filigghedu, Maria Teresa; Trujillo, Davinia; Costa, Ramon; Cadinanos, Julen (2014). “Systemic AA amyloidosis: epidemiology, diagnosis, and management”. Clinical Epidemiology: 369. doi:10.2147/CLEP.S39981. ISSN 1179-1349.
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