Sideroblastic anemia laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Nazia Fuad M.D.

Laboratory findings consistent with the diagnosis of sideroblastic anemia include decreased MCV, low reticulocyte count, increased ferritin levels, decreased total iron binding capacity. Hematocrit falls to 20-30%. Serum iron levels and transferrin saturation are high. In sideroblastic anemia associated with lead toxicity, basophilic stippling of red blood cells on peripheral smear is common. Prussian Blue stain of RBC in marrow shows ringed sideroblasts. Sideroblastic anemia that is associated with myelodysplastic syndrome (MDS) may show leukopenia, and thrombocytopenia,

Laboratory findings consistent with the diagnosis of sideroblastic anemia include:^[1]

• Microcytic hypochromic anemia
• Normal to low reticulocyte count
• Increased ferritin levels
• Decreased total iron-binding capacity
• Hematocrit 20-30%
• High serum Iron
• High transferrin saturation
• Basophilic stippling of red blood cells on peripheral blood smear in lead poisoning
• Prussian Blue stain of RBC in marrow, shows ringed sideroblasts
• Thrombocytopenia ( MDS association)
• Leukopenia

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