Sinus bradycardia pathophysiology
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]
Overview
Pathophysiology
This rhythm may be caused by one of the following:
- Increased vagal tone
- Intrinsic disease of the SA node
- An effect of drugs, such as the use of digitalis or beta-blockers
- Sleep
- Sinus bradycardia is a normal finding in a healthy, well-conditioned athlete
The HCN4 genetic variant is associated with sinus bradycardia. Certain sodium channelopathies are associated with sinus bradycardia.[1]
References
- ↑ Milanesi R, Baruscotti M, Gnecchi-Ruscone T, DiFrancesco D (2006). “Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel”. The New England Journal of Medicine. 354 (2): 151–7. doi:10.1056/NEJMoa052475. PMID 16407510. Retrieved 2011-02-23. Unknown parameter
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