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Sinusoidal obstruction syndrome diagnostic study of choice

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:

Overview

The two established criteria for the clinical diagnosis of sinusoidal obstruction syndrome are Baltimore criteria and modified Seattle criteria.

Diagnostic Criteria

The diagnosis of sinusoidal obstruction syndrome should be considered in any patient who has undergone hematopoietic cell transplant and develops liver dysfunction.

  • The two established criteria for the clinical diagnosis of sinusoidal obstruction syndrome are:[1][2][3]
Baltimore Criteria Seattle criteria
  • Within 30 days of transplantation, bilirubinemia > 34.2 mol/L (2 mg/dL), plus 2 other findings among the following:
    • Hepatomegaly, usually painful
    •  > 5% weight gain
    • Ascites
  • Within 20 days of transplantation, two of three findings among the following:
    • Bilirubin > 34.2 mol/L (2 mg/dL)
    • Hepatomegaly or RUQ pain of liver origin
    • > 2% weight gain due to fluid accumulation

References

  1. ↑ Valla DC, Cazals-Hatem D (2016). “Sinusoidal obstruction syndrome”. Clin Res Hepatol Gastroenterol. 40 (4): 378–85. doi:10.1016/j.clinre.2016.01.006. PMID 27038846.
  2. ↑ Gozdzik J, Krasowska-Kwiecień A, Wedrychowicz A (2008). “[Sinusoidal obstruction disease (SOS), previous hepatic venoocclusive disease (VOD)–still serious complication after hematopoietic stem cell transplantation]”. Prz. Lek. (in Polish). 65 (4): 203–8. PMID 18724548.
  3. ↑ McDonald GB, Sharma P, Matthews DE, Shulman HM, Thomas ED (1984). “Venocclusive disease of the liver after bone marrow transplantation: diagnosis, incidence, and predisposing factors”. Hepatology. 4 (1): 116–22. PMID 6363247.

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