Sinusoidal obstruction syndrome causes
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Husnain Shaukat, M.D [2]
Overview
The most common cause of sinusoidal obstruction syndrome is hematopoietic cell transplantation. Other less common causes include chemotherapeutic agents and pyrrolizidine alkaloids.
Causes
Common causes
- Sinusoidal obstruction syndrome is most commonly caused by hematopoietic cell transplantation.[1][2]
Less common causes
Other less common causes include:[3]
- Chemotherapeutic agents such as 6-mercaptopurine, 6-thioguanine, actinomycin D, azathioprine or busulfan etc
- Pyrrolizidine alkaloids
References
- ↑ McDonald GB, Hinds MS, Fisher LD, Schoch HG, Wolford JL, Banaji M, Hardin BJ, Shulman HM, Clift RA (1993). “Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients”. Ann. Intern. Med. 118 (4): 255–67. PMID 8420443.
- ↑ Kumar S, DeLeve LD, Kamath PS, Tefferi A (2003). “Hepatic veno-occlusive disease (sinusoidal obstruction syndrome) after hematopoietic stem cell transplantation”. Mayo Clin Proc. 78 (5): 589–98. doi:10.4065/78.5.589. PMID 12744547.
- ↑ Valla DC, Cazals-Hatem D (2016). “Sinusoidal obstruction syndrome”. Clin Res Hepatol Gastroenterol. 40 (4): 378–85. doi:10.1016/j.clinre.2016.01.006. PMID 27038846.
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