Sinusoidal obstruction syndrome classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Husnain Shaukat, M.D [2]

Overview

There is no established system for the classification of sinusoidal obstruction syndrome. However, it can be classified on the basis of severity as mild, moderate and severe.

Classification

There is no established system for the classification of sinusoidal obstruction syndrome. However, it can be classified on the basis of severity as mild, moderate and severe.^[1]

Parameters	Mild	Moderate	Severe
Serum total bilirubin	<5 mg/dL	< (5.1 to 8 mg/dL	>8 mg/dL
Serum aspartate aminotransferase (AST)	<3 x normal	3 to 8 x normal	>8 x normal
Weight above baseline	<2 percent	2 to 5 percent	>5 percent
Serum creatinine	Normal	<2 x normal	>2 x normal
Rate of change	Slow (over 6–7 d)	(over 4–5 d)	Rapid (over2–3 d)

References

↑ Chao N (2014). “How I treat sinusoidal obstruction syndrome”. Blood. 123 (26): 4023–6. doi:10.1182/blood-2014-03-551630. PMID 24833355.

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[pmid24833355-1] Chao N (2014). “How I treat sinusoidal obstruction syndrome”. Blood. 123 (26): 4023–6. doi:10.1182/blood-2014-03-551630. PMID 24833355.

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