Staphylococcal scalded skin syndrome differential diagnosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Unlike toxic epidermal necrolysis, SSSS spares the mucous membranes. Skin biopsy may show separation of the superficial layer of the epidermis, differentiating SSSS from TEN, wherein the epidermal-dermal layer is separated in the latter. SSSS may be difficult to distinguish from toxic epidermal necrolysis and pustular psoriasis.

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