Subependymal giant cell astrocytoma secondary prevention

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2], Ifeoma Odukwe, M.D. [3]

Effective measures for the secondary prevention of subependymal giant cell astrocytoma include brain imaging, preferably magnetic resonance imaging with and without contrast, which should be performed every 1 to 3 years until the age of 25 years in every patient with tuberous sclerosis.

Effective measures for the secondary prevention of subependymal giant cell astrocytoma include:^[1]

• Brain imaging, preferably magnetic resonance imaging with and without contrast, should be performed every 1 to 3 years until the age of 25 years in every patient with tuberous sclerosis.
• Follow-up magnetic resonance imaging may not be needed every 3 years, but intervals may be prolonged in the presence of a stable lesion and a stable patient.
• Screening and follow-up scans frequency should be tailored according to various clinical factors.

• New onset of symptoms such as headache, visual complaints, nausea, vomiting, or increase in seizure activity should warrant an earlier MRI scan.
• Similarly, a growing subependymal giant cell astrocytoma should prompt a more frequent clinical and radiological follow-up.

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