Syphilis other diagnostic studies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aysha Anwar, M.B.B.S [2]

Overview

Other diagnostic studies which may help diagnose complications of syphilis are CSF examination, screening tests for other STIs such as HIV, chlamydia, gonorrhea, and biopsy.^[1]^[2]

Other Diagnostic Studies

Other diagnostic studies which may help diagnose complications of syphilis are:^[1]^[2]

CSF examination

May help to diagnose neurosyphilis
Includes CSF cell count or protein and a reactive CSF-VDRL or CSF FTA-ABS test
CSF-VDRL is highly specific but insensitive
CSF FTA-ABS test is less specific for neurosyphilis than the CSF-VDRL but is highly sensitive

Screening tests for other STIs

Includes HIV, chlamydia, and gonorrhea

Biopsy

Biopsy may be considered if clinical findings do not correlate with negative serological tests and there is a strong index of suspicion for syphilis.

References

↑ ^1.0 ^1.1 http://www.cdc.gov/std/tg2015/syphilis.htm accessed on September 28, 2016
↑ ^2.0 ^2.1 Luger AF, Schmidt BL, Kaulich M (2000). “Significance of laboratory findings for the diagnosis of neurosyphilis”. Int J STD AIDS. 11 (4): 224–34. PMID 10772085.

Template:WikiDoc Sources

[CDC2016-1] 1.0 ^1.1 http://www.cdc.gov/std/tg2015/syphilis.htm accessed on September 28, 2016

[pmid10772085-2] 2.0 ^2.1 Luger AF, Schmidt BL, Kaulich M (2000). “Significance of laboratory findings for the diagnosis of neurosyphilis”. Int J STD AIDS. 11 (4): 224–34. PMID 10772085.

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