T-cell prolymphocytic leukemia causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Qurrat-ul-ain Abid, M.D.[2], Maria Fernanda Villarreal, M.D. [3]

T-cell prolymphocytic leukemia is caused by gene mutations and chromosomal abnormalities. Details of which are described below.

Common causes of T-cell prolymphocytic leukemia, include genetic factors and chromosomal abnormalities:^[1]

• Trisomy 8, chromosomal abnormalities
• Ataxia telangiectasia (ATM) gene mutation
• TP53 gene mutation

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