T-cell prolymphocytic leukemia physical examination

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Qurrat-ul-ain Abid, M.D.[2], Maria Fernanda Villarreal, M.D. [3]

On physical examination, the patient appears pale due to anemia. Splenomegaly and hepatomegaly on abdominal examination.

• Patients with T-cell prolymphocytic leukemia usually appear pale and malnourished.
• Physical examination may be remarkable for:^[1]

• Hepatomegaly
• Splenomegaly
• Generalized lymphadenopathy
• Skin infiltration
• Serous effusions:
  • Pleural effusion
  • Peritoneal effusion
• Central nervous system involvement (very rare)

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