TRIM69

Tripartite motif containing 69 is a protein that in humans is encoded by the TRIM69 gene. ^[1]

This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.