Thin basement membrane disease history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Marufa Marium, M.B.B.S[2]

Obtaining complete history both for the patient and family is an important aspect of diagnosing TBMD. The hallmark of TBMD is benign hematuria. A positive family history of incidental finding of intermittent or persistent hematuria is suggestive of TBMD. TBMD is mostly asymptomatic. Microscopic hematuria is found incidentally.

Obtaining complete medical and family history is an important aspect of diagnosing TBMD. It provides insight to cause and differentiation of TBMD with Alport syndrome, IgA nephropathy, Lupus Nephritis and other glomerulopathies. History may be obtained focusing specific areas including:

• Past medical history including URTI, Autoimmune Disease, Glomerulopathies.
• Positive family history of benign intermittent or persistent hematuria.
• Physical properties of urine (color, turbidity).
• Nature of micturation (frequency, dysuria)
• New onset hypertension or edema.

TBMD is mostly asymptomatic. The following signs are included:

• Intermiitent or persistent hematuria is found incidentally.
• New onset hypertension.
• Proteinuria.
• Renal impairment.
• Renal failure.

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