Thrombotic thrombocytopenic purpura physical examination

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]

The presence of fever, purpura, petechiae, paleness in physical examination is highly suggestive of TTP.

• Bruising may be present even in mucous membrane called purpura
• Pinpoint dots on skin called petechiae
• Paleness
• Jaundice

• Tachycardia

• Dyspnea
• Arrhythmia
• Severe complications; sudden cardiac death, myocardial infarction, cardiogenic shock, heart failure

• No abnormalities
• Moderate signs ^[1]; speech changes, confusion
• Severe involvement: focal signs, seizure, stroke, coma

Renal

• Fever

• Dark urine

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