Thrombotic thrombocytopenic purpura screening

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]

There is no insufficient evidence to recommend routine screening for TTP.

• There is no insufficient evidence to recommend routine screening for TTP.^[1]
• First test to be screening for ADAMTS13 activity. ADAMTS13 activity < 10%, TTP diagnosis is confirmed.
• In sever deficiency of ADAMTS13 second screening is detection of anti-ADAMTS13 IgG

• Gene sequencing of ADAMTS13 is a third test is used.

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