Transfusion-associated graft versus host disease primary prevention

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Prevention includes gamma irradiation of the lymphocyte-containing blood products. This procedure should be performed in transfusions when:

• the recipient is immunocompromised
• the blood components are from a family donor
• HLA-matched platelets are transferred.

Another means of prevention is the use of third- or fourth-generation leukoreduction filters, although the efficacy of this procedure has not yet been documented.

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