Tricyclic antidepressant overdose history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]

The peripheral autonomic nervous system, central nervous system and the heart are the main systems that are affected following overdose. Initial or mild symptoms typically develop within 2 hours and include:

• Tachycardia
• Drowsiness
• A dry mouth
• Nausea and vomiting
• Urinary retention
• Confusion
• Agitation
• Headache.

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