Tuberous sclerosis cost-effectiveness of therapy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: José Eduardo Riceto Loyola Junior, M.D.[2]

The treatment of tuberous sclerosis can be expensive, especially considering that many complications have surgical options for treatment.

A study from 2016 showed that for children with TSC presenting with refractory epilepsy (defined by the persistence of seizures despite the use of 2 anti-seizure drugs), the most cost-effective measure between resective epilepsy surgery, vagus nerve stimulator implantation, ketogenic diet, and addition of a third anti-seizure drug, was the addition of a third drug into the medication regimen,^[1]