Tylosis

Tylosis is an autosomal dominant disorder. In tylosis, there is hyperkeratinization of palms and soles. Though a rare disease, it is known to predispose to squamous cell carcinoma of the esophagus.

• Howel-Evans syndrome

• Online Mendelian Inheritance in Man (OMIM) 148500
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• PMID 9609757 “Tylosis esophageal cancer locus on chromosome 17q25.1 is commonly deleted in sporadic human esophageal cancer.”

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