USP18
Ubiquitin specific peptidase 18 (USP18), also known as UBP43, is an isopeptidase that in human is encoded by the USP18 gene.[1] USP18 is a member of the deubiquitinating protease family of enzymes. It is thought to remove ISG15 adducts from a broad range of protein substrates, a process known as deISGylation.[1] In mice, deletion of this enzyme results in increased inflammatory response to type I interferons, suggesting that USP18 may, in part, regulate interferon responsiveness.[2]
References
- ↑ 1.0 1.1 “Entrez Gene: USP18 ubiquitin specific peptidase 18”.
- ↑ “USP18 ubiquitin specific peptidase 18 [Homo sapiens (human)] – Gene – NCBI”. www.ncbi.nlm.nih.gov. Retrieved 2018-01-03.
Further reading
- Li XL, Blackford JA, Judge CS, Liu M, Xiao W, Kalvakolanu DV, Hassel BA (March 2000). “RNase-L-dependent destabilization of interferon-induced mRNAs. A role for the 2-5A system in attenuation of the interferon response”. The Journal of Biological Chemistry. 275 (12): 8880–8. doi:10.1074/jbc.275.12.8880. PMID 10722734.
- Schwer H, Liu LQ, Zhou L, Little MT, Pan Z, Hetherington CJ, Zhang DE (April 2000). “Cloning and characterization of a novel human ubiquitin-specific protease, a homologue of murine UBP43 (Usp18)”. Genomics. 65 (1): 44–52. doi:10.1006/geno.2000.6148. PMID 10777664.
- Kang D, Jiang H, Wu Q, Pestka S, Fisher PB (April 2001). “Cloning and characterization of human ubiquitin-processing protease-43 from terminally differentiated human melanoma cells using a rapid subtraction hybridization protocol RaSH”. Gene. 267 (2): 233–42. doi:10.1016/S0378-1119(01)00384-5. PMID 11313150.
- Malakhov MP, Malakhova OA, Kim KI, Ritchie KJ, Zhang DE (March 2002). “UBP43 (USP18) specifically removes ISG15 from conjugated proteins”. The Journal of Biological Chemistry. 277 (12): 9976–81. doi:10.1074/jbc.M109078200. PMID 11788588.
- Tokarz S, Berset C, La Rue J, Friedman K, Nakayama K, Nakayama K, Zhang DE, Lanker S (November 2004). “The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCFSkp2 ubiquitin ligase”. The Journal of Biological Chemistry. 279 (45): 46424–30. doi:10.1074/jbc.M403189200. PMID 15342634.
- Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). “From ORFeome to biology: a functional genomics pipeline”. Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Yan M, Luo JK, Ritchie KJ, Sakai I, Takeuchi K, Ren R, Zhang DE (July 2007). “Ubp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signaling”. Blood. 110 (1): 305–12. doi:10.1182/blood-2006-07-033209. PMC 1896118. PMID 17374743.
- Ketscher L, Hannß R, Morales DJ, Basters A, Guerra S, Goldmann T, Hausmann A, Prinz M, Naumann R, Pekosz A, Utermöhlen O, Lenschow DJ, Knobeloch KP (February 2015). “Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance” (PDF). Proceedings of the National Academy of Sciences of the United States of America. 112 (5): 1577–82. doi:10.1073/pnas.1412881112. PMC 4321242. PMID 25605921.
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