Undifferentiated connective tissue disease classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]

Overview

Undifferentiated connective tissue disorder (UCTD) are actually a group of disorders that are unclassified in other connective tissue disorders. UCTD may be classified according to the criteria developed by American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR) into: early Raynaud’s phenomenon, early inflammatory arthritis that is not classified as rheumatoid arthritis, some manifestations same as that of inflammatory myopathy, systemic lupus erythematosus, Sjögren’s syndrome, vasculitis, serositis, or interstitial lung disease which don’t meet diagnostic criteria for each of them and early scleroderma.

Classification

Undifferentiated connective tissue disorder (UCTD) are actually a group of disorders that are unclassified in other connective tissue disorders.^[1]^[2]
UCTD may be classified according to criteria developed by American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR) :^[3]
- Early Raynaud’s phenomenon
- Early inflammatory arthritis that is not classified as rheumatoid arthritis
- Some manifestations same as that of inflammatory myopathy, systemic lupus erythematosus, Sjögren’s syndrome, vasculitis, serositis, or interstitial lung disease which don’t meet diagnostic criteria for each of them
- Early scleroderma

References

↑ Mosca M, Tani C, Vagnani S, Carli L, Bombardieri S (2014). “The diagnosis and classification of undifferentiated connective tissue diseases”. J. Autoimmun. 48-49: 50–2. doi:10.1016/j.jaut.2014.01.019. PMID 24518855.
↑ Mosca M, Neri R, Bombardieri S (1999). “Undifferentiated connective tissue diseases (UCTD): a review of the literature and a proposal for preliminary classification criteria”. Clin. Exp. Rheumatol. 17 (5): 615–20. PMID 10544849.
↑ Costenbader KH, Schur PH (May 2015). “We need better classification and terminology for “people at high risk of or in the process of developing lupus““. Arthritis Care Res (Hoboken). 67 (5): 593–6. doi:10.1002/acr.22484. PMC 4391980. PMID 25302656.

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[pmid24518855-1] Mosca M, Tani C, Vagnani S, Carli L, Bombardieri S (2014). “The diagnosis and classification of undifferentiated connective tissue diseases”. J. Autoimmun. 48-49: 50–2. doi:10.1016/j.jaut.2014.01.019. PMID 24518855.

[pmid10544849-2] Mosca M, Neri R, Bombardieri S (1999). “Undifferentiated connective tissue diseases (UCTD): a review of the literature and a proposal for preliminary classification criteria”. Clin. Exp. Rheumatol. 17 (5): 615–20. PMID 10544849.

[pmid25302656-3] Costenbader KH, Schur PH (May 2015). “We need better classification and terminology for “people at high risk of or in the process of developing lupus““. Arthritis Care Res (Hoboken). 67 (5): 593–6. doi:10.1002/acr.22484. PMC 4391980. PMID 25302656.

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