Upper gastrointestinal bleeding historical perspective

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]

Alessandro Benedetti was the first to give a detalied description of stomach in 1947. In 1543, Vesalius, a Belgian anatomist was the first to describe the anatomy of the esophagus. In 1682, D Zollikofer was the first to perform sclerotherapy by injecting an acid into a vein to induce thrombus formation. Asklepios was the first to describe association between GI bleeding and peptic ulcer disease.

• In 1497, Alessandro Benedetti was the first to give a detailed description of stomach and its anatomy.
• In 1543, Vesalius, a Belgian anatomist was the first to describe the anatomy of the esophagus.^[1]
• In 1682, D Zollikofer was the first to perform sclerotherapy by injecting an acid into a vein to induce thrombus formation.^[2]
• In 1853, Debout and Cassaignaic reported success in treating varicose veins by injecting perchlorate of iron.^[3]
• Endoscopic injection of bleeding peptic ulcers with adrenaline has been practiced since the 1970s.^[3]
• In 1982: D. Fleischer was the first to use an endoscopic laser as palliative therapy for esophageal carcinoma.
• In 1929, Coppleson was the first to advocate the use of sodium salicylate or quinine as the best choices of sclerosant.^[2]
• In 1982: D. Fleischer was the first to use an endoscopic laser as palliative therapy for esophageal carcinoma.
• Prof. Sicard developed the use of sodium carbonate and then sodium salicylate during and after the First World War as a sclerosant.
• Asklepios was the first to describe association between GI bleeding and peptic ulcer disease.

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