Uveal melanoma classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Fahimeh Shojaei, M.D., Simrat Sarai, M.D. [2]

Overview

Uveal melanoma may be classified according to cell type into 5 subtypes: Spindle A, spindle B, epitheliolid, mixed, and necrotic. Uveal melanoma may also be classified according to its location into 2 types, anterior uveal melanoma which contain iris melanoma, and posterior uveal melanoma which contains ciliary body melanoma and chroidal melanoma.

Uveal melanoma may be classified according to cell type into 5 subtypes: Spindle A, spindle B, epitheliolid, mixed, and necrotic.^[1]

Cell type	Explanation
Spindle A	Fine nuclear chromatin Cells with small spindle nuclei and central dark stripe No distinct nucleoli Rare mitotic features
Spindle B	Commen Coarse nuclear chromatin Distinct nucleoli Rare mitotic features
Epithelioid	Rarest Large round nuclei Prominent nucleoli Mitotic features are common
Mixed	Most common Contains both spindle cells and epithelioil cells
Necrotic	uncommon Necrotic tumor with unidentifiable cell type

Uveal melanoma may also be classified according to its location into 2 types:

↑ McLean, Ian W.; Foster, Walter D.; Zimmerman, Lorenz E.; Gamel, John W. (1983). “Modifications of Callender’s Classification of Uveal Melanoma at the Armed Forces Institute of Pathology”. American Journal of Ophthalmology. 96 (4): 502–509. doi:10.1016/S0002-9394(14)77914-0. ISSN 0002-9394.