VIPoma history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Madhu Sigdel M.B.B.S.[2]Parminder Dhingra, M.D. [3] Homa Najafi, M.D.[4]

The hallmark of Vipoma is watery diarrhea. A positive history of abdominal pain, weight loss, numbness, and weakness is suggestive of VIPoma . The most common symptoms of VIPoma include watery diarrhea like cholera, dehydration, lethargy, muscle weakness, weight loss, numbness, and flushing.

• The hallmark of Vipoma is watery diarrhea. A positive history of abdominal pain, weight loss, numbness, and weakness is suggestive of VIPoma . The most common symptoms of VIPoma include watery diarrhea like cholera, dehydration, lethargy, muscle weakness, weight loss, numbness, and flushing.

Patients with VIPoma may have a positive history of:

• Watery diarrhea
• Abdominal pain
• Weakness

Symptoms of VIPoma usually arise when tumor reaches certain size. Most tumors are > 2cm and metastatic by the time symptoms arise. Common symptoms may include any of the following:^[1][2][3][4]

• Watery diarrhea like cholera
  • Volume ranges from 750ml to more than 3 liters.
  • Secretory diarrhea persists even on fasting for 48 hours and is odorless.
  • The stool appears like dilute tea in color, is blood and mucus free.
• Dehydration (thirst, dry skin, dry mouth, tiredness, headaches, and dizziness)
• Lethargy
• Muscle weakness
• Weight loss
• Numbness caused due to hypokalaemia
• Flushing

• Crampy abdominal pain
• Nausea
• Vomiting

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