VIPoma laboratory findings
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Madhu Sigdel M.B.B.S.[2] Homa Najafi, M.D.[3]
Overview
Laboratory tests used in the diagnosis of VIPoma include serum vasoactive intestinal polypeptide (VIP) levels, basal gastric acid output, and CMP for potassium, bicarbonate, magnesium, and calcium levels.
Laboratory Findings
Laboratory findings consistent with the diagnosis of VIPoma include:[1][2]
- Elevated serum vasoactive intestinal polypeptide (VIP) levels:
- Normal fasting serum VIP level is generally < 75 pg/ml
- In VIPomas levels of VIP is generally > 500 pg/ml.
- VIP level > 200pg/ml is strongly suggestive of VIPoma.
- Hormone measurement taken at the time of diarrheal episode has the highest yield as VIP secretion during period of diarrhea and has short t1/2 (approx. 2 mins in blood).
- Single measurement should be confirmed by repeat testing.
- Elevated pancreatic polypeptide levels (Normal < 312 pg/ml) and neurotensin levels.
- Low serum potassium, bicarbonate, and magnesium levels secondary to fecal loss.
- High calcium levels secondary to fecal loss.
- Low basal gastric acid output.
References
- ↑ Ito T, Igarashi H, Jensen RT (2012). “Pancreatic neuroendocrine tumors: clinical features, diagnosis and medical treatment: advances”. Best Pract Res Clin Gastroenterol. 26 (6): 737–53. doi:10.1016/j.bpg.2012.12.003. PMC 3627221. PMID 23582916.
- ↑ Nilubol N, Freedman EM, Quezado MM, Patel D, Kebebew E (2016). “Pancreatic Neuroendocrine Tumor Secreting Vasoactive Intestinal Peptide and Dopamine With Pulmonary Emboli: A Case Report”. J Clin Endocrinol Metab. 101 (10): 3564–3567. doi:10.1210/jc.2016-2051. PMC 5052354. PMID 27583474.
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