WBP4
WW domain-binding protein 4 is a protein that in humans is encoded by the WBP4 gene.[1][2]
This gene encodes WW domain-containing binding protein 4. The WW domain represents a small and compact globular structure that interacts with proline-rich ligands. This encoded protein is a general spliceosomal protein that may play a role in cross-intron bridging of U1 and U2 snRNPs in the spliceosomal complex A.[2]
References
- ↑ Bedford MT, Reed R, Leder P (Sep 1998). “WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif”. Proc Natl Acad Sci U S A. 95 (18): 10602–7. doi:10.1073/pnas.95.18.10602. PMC 27941. PMID 9724750.
- ↑ 2.0 2.1 “Entrez Gene: WBP4 WW domain binding protein 4 (formin binding protein 21)”.
Further reading
- Takahara T, Tasic B, Maniatis T, et al. (2005). “Delay in synthesis of the 3′ splice site promotes trans-splicing of the preceding 5′ splice site”. Mol. Cell. 18 (2): 245–51. doi:10.1016/j.molcel.2005.03.018. PMID 15837427.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Dunham A, Matthews LH, Burton J, et al. (2004). “The DNA sequence and analysis of human chromosome 13”. Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Bedford MT, Frankel A, Yaffe MB, et al. (2000). “Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains”. J. Biol. Chem. 275 (21): 16030–6. doi:10.1074/jbc.M909368199. PMID 10748127.
- Chan DC, Bedford MT, Leder P (1996). “Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains”. EMBO J. 15 (5): 1045–54. PMC 450002. PMID 8605874.
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