Granulomatosis with polyangiitis laboratory findings
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]Amandeep Singh M.D.[4]
Overview
Laboratory findings consistent with the diagnosis of Granulomatosis with polyangiitis include, anti-neutrophil cytoplasmic antibody, elevated blood urea nitrogen, elevated creatinine serum, erythrocyte sedimentation rate, C reactive protein, proteinuria, microscopic hematuria, and red blood casts.
Laboratory Findings
Laboratory findings consistent with the diagnosis of Granulomatosis with polyangiitis include, anti-neutrophil cytoplasmic antibody, elevated blood urea nitrogen, elevated creatinine serum, erythrocyte sedimentation rate, C reactive protein, proteinuria, microscopic hematuria, and red blood casts.
Blood Work-Up
- Complete blood count
- Serum Creatinine
- Blood urea nitrogen
- Anti-neutrophil cytoplasmic antibody test
- Anti PR3
Urinalysis
- Proteinuria
- Microscopic hematuria
- Red cell casts
Renal Biopsy
Renal biopsy is the gold standard in establishing Granulomatosis with polyangiitis.[1] Renal biopsy reveals under electron microscopy:
- Subendothelial edema
- Microthrombosis, and
- Degranulation of neutrophils.
Under light microscopy, necrotizing and crescentic glomerulonephritis is seen. [2]
References
- ↑ Berden AE, Ferrario F, Hagen EC, Jayne DR, Jennette JC, Joh K; et al. (2010). “Histopathologic classification of ANCA-associated glomerulonephritis”. J Am Soc Nephrol. 21 (10): 1628–36. doi:10.1681/ASN.2010050477. PMID 20616173.
- ↑ Bajema IM, Hagen EC, Ferrario F, de Heer E, Bruijn JA (2001). “Immunopathological aspects of systemic vasculitis”. Springer Semin Immunopathol. 23 (3): 253–65. PMID 11591101.
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