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Zollinger-Ellison syndrome epidemiology and demographics

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]

Overview

The incidence of gastrinoma, which can cause Zollinger-Ellison syndrome, is approximately 0.05 – 0.2 per 100,000 individuals worldwide. About 25 to 30 percent of gastrinomas are caused by multiple endocrine neoplasia type 1 (MEN1).

Epidemiology and Demographics

Incidence

  • The worldwide incidence of gastrinomas is about 5 to 30 cases per 100,000 individuals per year.[1]
  • With improved techniques for tumor detection, the annual incidence has increased.
  • About 80% to 90% of these tumors arise in the gastrinoma triangle.

Age

  • Zollinger-Ellison syndrome is a disease that tends to affect the middle-aged adult population (20 – 50 years of age).[2]

Gender

  • Males are more commonly affected with Zollinger-Ellison syndrome than females.[2]

Race

  • There is no racial predilection to Zollinger-Ellison syndrome

References

  1. Cingam SR, Karanchi H. PMID 28722872. Missing or empty |title= (help)
  2. 2.0 2.1 Berna MJ, Hoffmann KM, Serrano J, Gibril F, Jensen RT (2006). “Serum gastrin in Zollinger-Ellison syndrome: I. Prospective study of fasting serum gastrin in 309 patients from the National Institutes of Health and comparison with 2229 cases from the literature”. Medicine (Baltimore). 85 (6): 295–330. doi:10.1097/01.md.0000236956.74128.76. PMID 17108778.

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