Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
17-beta-hydroxysteroid dehydrogenase deficiency causes
Introduction
Overview
Overview
HSD17B3 gene mutation causes 17-beta hydroxysteroid dehydrogenase deficiency results a decrease in testosterones production. The reduction of testosterones affects the development of male reproductive tract which results phenotypically female or ambiguous external genitalia.
Causes
Causes
- HSD17B3 gene mutation causes 17-beta hydroxysteroid dehydrogenase deficiency results a decrease in testosterones production.
- The reduction of testosterones affects the development of male reproductive tract which results phenotypically female or ambiguous external genitalia.
- At puberty, in some of affected individuals, the production of testosterone rises through conversion of androstenedione to testosterone in different tissues of the body involving other enzymes.
- The increase in testosterone level results in the development of male secondary sex characteristics in adolescents.
References
References
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Abdulkerim Yassin, M.B.B.S[2]