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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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2-hydroxyphytanoyl-CoA lyase

Introduction

2-Hydroxyphytanoyl-CoA lyase is a peroxisomal enzyme involved in the catabolism of phytanoic acid by α-oxidation. It requires thiamine diphosphate (ThDP) as cofactor.[1]

It is classified under EC number 4.1.

File:Alpha oxidation part III.svg

References

References

  1. ↑ Foulon V, Antonenkov V, Croes K, et al. (1999). “Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids”. Proc. Natl. Acad. Sci. U.S.A. 96 (18): 10039–44. doi:10.1073/pnas.96.18.10039. PMC 17838. PMID 10468558.
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