Surgical options depends on the presenting symptom at the time of diagnosis and can vary from cardiac sugery to a simple Cleft palate surgery. Thymic Transplantation becomes an obvious choice in a complete DGS case.

• Patients with 22q11.2 deletion syndrome may undergo cardiac surgery for their heart abnormalities.

• Cleft palate cases require evaluation by an otolaryngologist, plastic surgeon, or oral & maxillofacial surgeon with experience in surgical correction of palatal defects. Repair of a cleft palate can improve feeding ability, speech, and reduce the incidence of sinopulmonary infections.
• Thymic transplantations is preferred in complete DGS .