
Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
2C-F
Introduction
2C-F, or 4-fluoro-2,5-dimethoxyphenethylamine, is a lesser-known psychedelic drug of the 2C family. It was first synthesized by Alexander Shulgin. In his book PIHKAL (Phenethylamines I Have Known and Loved), the minimum dosage is listed as 250 mg. 2C-F may be found as a brownish freebase oil, or as a white crystalline hydrochloride salt.
Dosage and Effects
Dosage and Effects
Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-F. At a dose of 250 milligrams, 2C-F produces modest closed-eye visuals accompanied by lethargy [1]. The amphetamine analogue DOF is likely to be more active than the phenethylamine derivative 2C-F, and in animal trials DOF was found to be 1/6th the dosage of the potent hallucinogen DOI, which would make an active dose of DOF likely to be in the 6-18 milligram range, although it is not known to have been tested in humans.
