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4-dimethylaminophenol

Introduction

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Overview

Overview

4-Dimethylaminophenol (abbreviated in medical practice as DMAP) is an aromatic compound containing both phenol and amine functional groups. It has the molecular formula C8H11NO.

Uses

Uses

4-Dimethylaminophenol has been used as an antidote for cyanide poisoning.It has also been shown to be effective in treating hydrogen sulfide toxicity.

It works by generating methemoglobin.

This is suitable as an emergency treatment only; treatment must be followed up with sodium thiosulfate or cobalamin.

In an animal model, it has shown effectiveness when given intramuscularly.Though, intramuscular injection should be avoided due to the probability of muscular necrosis after injection. Intravenous injection is recommended in a dose of 250mg.

References

References

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]