Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
ABCC13
Introduction
Putative ATP-binding cassette transporter sub-family C member 13 is a protein that in humans is encoded by the ABCC13 gene.[1]
Function
Function
This gene is a member of the superfamily of genes encoding ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This family member is part of the MRP subfamily, which is involved in multi-drug resistance, but the human locus is now thought to be a pseudogene incapable of encoding a functional ABC protein. Alternative splicing results in multiple transcript variants; however, not all variants have been fully described.[1]
See also
See also
- ATP-binding cassette transporter
- ABCC13+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
References
References
Further reading
Further reading
- Dean M, Annilo T (2005). “Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates”. Annual Review of Genomics and Human Genetics. 6: 123–42. doi:10.1146/annurev.genom.6.080604.162122. PMID 16124856.
- Annilo T, Dean M (Jul 2004). “Degeneration of an ATP-binding cassette transporter gene, ABCC13, in different mammalian lineages”. Genomics. 84 (1): 34–46. doi:10.1016/j.ygeno.2004.02.010. PMID 15203202.
- Hillman RT, Green RE, Brenner SE (2005). “An unappreciated role for RNA surveillance”. Genome Biology. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
- Brun ME, Ruault M, Ventura M, Roizès G, De Sario A (Jul 2003). “Juxtacentromeric region of human chromosome 21: a boundary between centromeric heterochromatin and euchromatic chromosome arms”. Gene. 312: 41–50. doi:10.1016/S0378-1119(03)00530-4. PMID 12909339.
- Yabuuchi H, Takayanagi S, Yoshinaga K, Taniguchi N, Aburatani H, Ishikawa T (Dec 2002). “ABCC13, an unusual truncated ABC transporter, is highly expressed in fetal human liver”. Biochemical and Biophysical Research Communications. 299 (3): 410–7. doi:10.1016/S0006-291X(02)02658-X. PMID 12445816.
- Gardiner K, Slavov D, Bechtel L, Davisson M (Jun 2002). “Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis”. Genomics. 79 (6): 833–43. doi:10.1006/geno.2002.6782. PMID 12036298.
- Allikmets R, Gerrard B, Hutchinson A, Dean M (Oct 1996). “Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database”. Human Molecular Genetics. 5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID 8894702.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.