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ABCF2
Introduction
ATP-binding cassette sub-family F member 2 is a protein that in humans is encoded by the ABCF2 gene.[1][2]
Function
Function
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This protein is a member of the GCN20 subfamily. Alternative splicing of this gene results in multiple transcript variants.[2]
ABCF2 acts as a suppressor of the volume-sensitive outwardly rectifying Cl channel (CLCN3).[3]
References
References
- β Allikmets R, Gerrard B, Hutchinson A, Dean M (October 1996). “Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database”. Human Molecular Genetics. 5 (10): 1649β55. doi:10.1093/hmg/5.10.1649. PMIDΒ 8894702.
- β 2.0 2.1 “Entrez Gene: ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2”.
- β Ando-Akatsuka Y, Shimizu T, Numata T, Okada Y (2012). “Involvements of the ABC protein ABCF2 and Ξ±-actinin-4 in regulation of cell volume and anion channels in human epithelial cells”. Journal of Cellular Physiology. 227 (10): 3498β510. doi:10.1002/jcp.24050. PMIDΒ 22252987.
Further reading
Further reading
- Klein I, Sarkadi B, VΓ‘radi A (December 1999). “An inventory of the human ABC proteins”. Biochimica et Biophysica Acta. 1461 (2): 237β62. doi:10.1016/s0005-2736(99)00161-3. PMIDΒ 10581359.
- Dean M, Rzhetsky A, Allikmets R (July 2001). “The human ATP-binding cassette (ABC) transporter superfamily”. Genome Research. 11 (7): 1156β66. doi:10.1101/gr.184901. PMIDΒ 11435397.
- Hogue DL, Liu L, Ling V (January 1999). “Identification and characterization of a mammalian mitochondrial ATP-binding cassette membrane protein”. Journal of Molecular Biology. 285 (1): 379β89. doi:10.1006/jmbi.1998.2259. PMIDΒ 9878413.
- Zhang F, Hogue DL, Liu L, Fisher CL, Hui D, Childs S, Ling V (July 2000). “M-ABC2, a new human mitochondrial ATP-binding cassette membrane protein”. FEBS Letters. 478 (1β2): 89β94. doi:10.1016/S0014-5793(00)01823-8. PMIDΒ 10922475.
- Ye Z, Connor JR (August 2000). “cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs”. Biochemical and Biophysical Research Communications. 275 (1): 223β7. doi:10.1006/bbrc.2000.3282. PMIDΒ 10944468.
- Stanchi F, Bertocco E, Toppo S, Dioguardi R, Simionati B, Cannata N, Zimbello R, Lanfranchi G, Valle G (January 2001). “Characterization of 16 novel human genes showing high similarity to yeast sequences”. Yeast. 18 (1): 69β80. doi:10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H. PMIDΒ 11124703.
- Tsuda H, Ito YM, Ohashi Y, Wong KK, Hashiguchi Y, Welch WR, Berkowitz RS, Birrer MJ, Mok SC (October 2005). “Identification of overexpression and amplification of ABCF2 in clear cell ovarian adenocarcinomas by cDNA microarray analyses”. Clinical Cancer Research. 11 (19 Pt 1): 6880β8. doi:10.1158/1078-0432.CCR-05-0751. PMIDΒ 16203778.
- Nishimura S, Tsuda H, Ito K, Jobo T, Yaegashi N, Inoue T, Sudo T, Berkowitz RS, Mok SC (January 2007). “Differential expression of ABCF2 protein among different histologic types of epithelial ovarian cancer and in clear cell adenocarcinomas of different organs”. Human Pathology. 38 (1): 134β9. doi:10.1016/j.humpath.2006.06.026. PMIDΒ 16996567.
External links
External links
- ABCF2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- ABCF2 human gene location in the UCSC Genome Browser.
- ABCF2 human gene details in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.