Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
ACSS3
Introduction
Acyl-CoA synthetase short-chain family member 3 is a protein that in humans is encoded by the ACSS3 gene.[1]
Function
Function
ACSS3 is part of a family known as Acyl-coenzyme A synthetases (ACSs), which catalyze the initial reaction in fatty acid metabolism. This reaction activates fatty acids via thioesterification to CoA, thereby allowing their participation in both anabolic and catabolic pathways. The existence of many ACSs suggests that each plays a unique role, directing the acyl-CoA product to a specific metabolic fate. Knowing the full complement of ACS genes in the human genome will facilitate future studies to characterize their specific biological functions.[2]
References
References
- ↑ “Entrez Gene: Acyl-CoA synthetase short-chain family member 3”.
- ↑ Watkins PA, Maiguel D, Jia Z, Pevsner J (Dec 2007). “Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome”. Journal of Lipid Research. 48 (12): 2736–50. doi:10.1194/jlr.M700378-JLR200. PMID 17762044.
Further reading
Further reading
- Hunter AM, Leuchter AF, Power RA, Muthén B, McGrath PJ, Lewis CM, Cook IA, Garriock HA, McGuffin P, Uher R, Hamilton SP (Sep 2013). “A genome-wide association study of a sustained pattern of antidepressant response”. Journal of Psychiatric Research. 47 (9): 1157–65. doi:10.1016/j.jpsychires.2013.05.002. PMC 3710535. PMID 23726668.
- Watkins PA, Maiguel D, Jia Z, Pevsner J (Dec 2007). “Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome”. Journal of Lipid Research. 48 (12): 2736–50. doi:10.1194/jlr.M700378-JLR200. PMID 17762044.