Health Dictionary
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ACTN1
Introduction
Actinin, alpha 1, also known as ACTN1, is a human gene.
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene.[1]
Further reading
Further reading
- Snásel J, Pichová I (1997). “The cleavage of host cell proteins by HIV-1 protease”. Folia Biol. (Praha). 42 (5): 227–30. PMID 8997639.
- Menko S, Philp N, Veneziale B, Walker J (1998). “Integrins and development: how might these receptors regulate differentiation of the lens”. Ann. N. Y. Acad. Sci. 842: 36–41. PMID 9599291.
- Yürüker B, Niggli V (1992). “Alpha-actinin and vinculin in human neutrophils: reorganization during adhesion and relation to the actin network”. J. Cell. Sci. 101 ( Pt 2): 403–14. PMID 1629252.
- Tokuue Y, Goto S, Imamura M; et al. (1992). “Transfection of chicken skeletal muscle alpha-actinin cDNA into nonmuscle and myogenic cells: dimerization is not essential for alpha-actinin to bind to microfilaments”. Exp. Cell Res. 197 (2): 158–67. PMID 1720388.
- Shoeman RL, Kesselmier C, Mothes E; et al. (1991). “Non-viral cellular substrates for human immunodeficiency virus type 1 protease”. FEBS Lett. 278 (2): 199–203. PMID 1991513.
- Nishiyama M, Ozturk M, Frohlich M; et al. (1990). “Expression of human alpha-actinin in human hepatocellular carcinoma”. Cancer Res. 50 (19): 6291–4. PMID 2169343.
- Youssoufian H, McAfee M, Kwiatkowski DJ (1990). “Cloning and chromosomal localization of the human cytoskeletal alpha-actinin gene reveals linkage to the beta-spectrin gene”. Am. J. Hum. Genet. 47 (1): 62–71. PMID 2349951.
- Millake DB, Blanchard AD, Patel B, Critchley DR (1989). “The cDNA sequence of a human placental alpha-actinin”. Nucleic Acids Res. 17 (16): 6725. PMIDÂ 2780298.
- Dubernard V, Faucher D, Launay JM, Legrand C (1995). “Identification of the cytoskeletal protein alpha-actinin as a platelet thrombospondin-binding protein”. FEBS Lett. 364 (2): 109–14. PMID 7750553.
- Knudsen KA, Soler AP, Johnson KR, Wheelock MJ (1995). “Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin”. J. Cell Biol. 130 (1): 67–77. PMID 7790378.
- Glück U, Ben-Ze’ev A (1995). “Modulation of alpha-actinin levels affects cell motility and confers tumorigenicity on 3T3 cells”. J. Cell. Sci. 107 ( Pt 7): 1773–82. PMID 7983147.
- Maruyama K, Sugano S (1994). “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1–2): 171–4. PMID 8125298.
- Egerton M, Moritz RL, Druker B; et al. (1996). “Identification of the 70kD heat shock cognate protein (Hsc70) and alpha-actinin-1 as novel phosphotyrosine-containing proteins in T lymphocytes”. Biochem. Biophys. Res. Commun. 224 (3): 666–74. doi:10.1006/bbrc.1996.1082. PMID 8713105.
- Mukai H, Toshimori M, Shibata H; et al. (1997). “Interaction of PKN with alpha-actinin”. J. Biol. Chem. 272 (8): 4740–6. PMID 9030526.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). “Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library”. Gene. 200 (1–2): 149–56. PMID 9373149.
- Hazan RB, Norton L (1998). “The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton”. J. Biol. Chem. 273 (15): 9078–84. PMID 9535896.
- Bunn RC, Jensen MA, Reed BC (1999). “Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton”. Mol. Biol. Cell. 10 (4): 819–32. PMID 10198040.
- Reinhard M, Zumbrunn J, Jaquemar D; et al. (1999). “An alpha-actinin binding site of zyxin is essential for subcellular zyxin localization and alpha-actinin recruitment”. J. Biol. Chem. 274 (19): 13410–8. PMID 10224105.