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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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ADFP

Introduction

Adipose differentiation-related protein, also known as ADFP, is a human gene.[1]

Adipocyte differentiation-related protein is associated with the globule surface membrane material. This protein is a major constituent of the globule surface. Increase in mRNA levels is one of the earliest indications of adipocyte differentiation[1]

References

References

  1. ↑ 1.0 1.1 “Entrez Gene: ADFP adipose differentiation-related protein”.
Further reading

Further reading

  • Jiang HP, Serrero G (1992). “Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related protein”. Proc. Natl. Acad. Sci. U.S.A. 89 (17): 7856–60. PMID 1518805.
  • Heid HW, Schnölzer M, Keenan TW (1997). “Adipocyte differentiation-related protein is secreted into milk as a constituent of milk lipid globule membrane”. Biochem. J. 320 ( Pt 3): 1025–30. PMID 9003395.
  • Heid HW, Moll R, Schwetlick I; et al. (1998). “Adipophilin is a specific marker of lipid accumulation in diverse cell types and diseases”. Cell Tissue Res. 294 (2): 309–21. PMID 9799447.
  • Schultz CJ, Torres E, Londos C, Torday JS (2002). “Role of adipocyte differentiation-related protein in surfactant phospholipid synthesis by type II cells”. Am. J. Physiol. Lung Cell Mol. Physiol. 283 (2): L288–96. doi:10.1152/ajplung.00204.2001. PMID 12114189.
  • Saarikoski ST, Rivera SP, Hankinson O (2002). “Mitogen-inducible gene 6 (MIG-6), adipophilin and tuftelin are inducible by hypoxia”. FEBS Lett. 530 (1–3): 186–90. PMID 12387890.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Targett-Adams P, Chambers D, Gledhill S; et al. (2003). “Live cell analysis and targeting of the lipid droplet-binding adipocyte differentiation-related protein”. J. Biol. Chem. 278 (18): 15998–6007. doi:10.1074/jbc.M211289200. PMID 12591929.
  • Bildirici I, Roh CR, Schaiff WT; et al. (2004). “The lipid droplet-associated protein adipophilin is expressed in human trophoblasts and is regulated by peroxisomal proliferator-activated receptor-gamma/retinoid X receptor”. J. Clin. Endocrinol. Metab. 88 (12): 6056–62. PMID 14671211.
  • Larigauderie G, Furman C, Jaye M; et al. (2005). “Adipophilin enhances lipid accumulation and prevents lipid efflux from THP-1 macrophages: potential role in atherogenesis”. Arterioscler. Thromb. Vasc. Biol. 24 (3): 504–10. doi:10.1161/01.ATV.0000115638.27381.97. PMID 14707038.
  • Nakamura N, Akashi T, Taneda T; et al. (2004). “ADRP is dissociated from lipid droplets by ARF1-dependent mechanism”. Biochem. Biophys. Res. Commun. 322 (3): 957–65. doi:10.1016/j.bbrc.2004.08.010. PMID 15336557.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
  • Robenek H, Lorkowski S, Schnoor M, Troyer D (2005). “Spatial integration of TIP47 and adipophilin in macrophage lipid bodies”. J. Biol. Chem. 280 (7): 5789–94. doi:10.1074/jbc.M407194200. PMID 15545278.
  • Masuda Y, Itabe H, Odaki M; et al. (2006). “ADRP/adipophilin is degraded through the proteasome-dependent pathway during regression of lipid-storing cells”. J. Lipid Res. 47 (1): 87–98. doi:10.1194/jlr.M500170-JLR200. PMID 16230742.
  • Tobin KA, Harsem NK, Dalen KT; et al. (2006). “Regulation of ADRP expression by long-chain polyunsaturated fatty acids in BeWo cells, a human placental choriocarcinoma cell line”. J. Lipid Res. 47 (4): 815–23. doi:10.1194/jlr.M500527-JLR200. PMID 16391323.
  • Dalen KT, Ulven SM, Arntsen BM; et al. (2006). “PPARalpha activators and fasting induce the expression of adipose differentiation-related protein in liver”. J. Lipid Res. 47 (5): 931–43. doi:10.1194/jlr.M500459-JLR200. PMID 16489205.
  • Ohsaki Y, Maeda T, Maeda M; et al. (2006). “Recruitment of TIP47 to lipid droplets is controlled by the putative hydrophobic cleft”. Biochem. Biophys. Res. Commun. 347 (1): 279–87. doi:10.1016/j.bbrc.2006.06.074. PMID 16808905.
  • Larigauderie G, Cuaz-Pérolin C, Younes AB; et al. (2006). “Adipophilin increases triglyceride storage in human macrophages by stimulation of biosynthesis and inhibition of beta-oxidation”. FEBS J. 273 (15): 3498–510. doi:10.1111/j.1742-4658.2006.05357.x. PMID 16884492.
  • Magra AL, Mertz PS, Torday JS, Londos C (2007). “Role of adipose differentiation-related protein in lung surfactant production: a reassessment”. J. Lipid Res. 47 (11): 2367–73. doi:10.1194/jlr.M600157-JLR200. PMID 16936283.
  • Yao M, Huang Y, Shioi K; et al. (2007). “Expression of adipose differentiation-related protein: a predictor of cancer-specific survival in clear cell renal carcinoma”. Clin. Cancer Res. 13 (1): 152–60. doi:10.1158/1078-0432.CCR-06-1877. PMID 17200350.
  • Sarov-Blat L, Kiss RS, Haidar B; et al. (2007). “Predominance of a proinflammatory phenotype in monocyte-derived macrophages from subjects with low plasma HDL-cholesterol”. Arterioscler. Thromb. Vasc. Biol. 27 (5): 1115–22. doi:10.1161/ATVBAHA.106.138990. PMID 17322100.

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