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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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AEBP2

Introduction

Adipocyte Enhancer-Binding Protein is a zinc finger protein that in humans is encoded by the evolutionarily well-conserved gene AEBP2. It was initially identified due to its binding capability to the promoter[1] of the adipocyte P2 gene, and was therefore named Adipocyte Enhancer Binding Protein 2. AEBP2 is a potential targeting protein for the mammalian Polycomb Repression Complex 2 (PRC2).[2]

Function

Function

AEBP2 is a DNA-binding transcriptional repressor. It may interact with and stimulate the activity of the PRC2 complex.[3]

AEBP2 may regulate the migration and development of the neural crest cells through the PRC2-mediated epigenetic mechanism and is most likely a targeting protein for the mammalian PRC2 complex.[4]

Clinical significance

Clinical significance

Diseases associated with AEBP2 include Waardenburg’s syndrome, and Hirschsprung’s disease.[4]

References

References

  1. ↑ Imhof, Axel; Kim, Hana; Bakshi, Arundhati; Kim, Joomyeong (2015). “Retrotransposon-Derived Promoter of Mammalian Aebp2”. PLOS ONE. 10 (4): e0126966. doi:10.1371/journal.pone.0126966. ISSN 1932-6203. PMC 4411029. PMID 25915901.
  2. ↑ Kim H, Kang K, Ekram MB, Roh TY, Kim J (2011). “Aebp2 as an epigenetic regulator for neural crest cells”. PLoS ONE. 6 (9): e25174. doi:10.1371/journal.pone.0025174. PMID 21949878.
  3. ↑ Cao R, Zhang Y (July 2004). “SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex”. Mol. Cell. 15 (1): 57–67. doi:10.1016/j.molcel.2004.06.020. PMID 15225548.
  4. ↑ 4.0 4.1 Kim H, Kang K, Kim J (2009). “AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2”. Nucleic Acids Res. 37 (9): 2940–50. doi:10.1093/nar/gkp149. PMID 19293275.
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