Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
ALDOC
Introduction
Aldolase C, fructose-bisphosphate, also known as ALDOC, is a human gene.[1]
This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively.[1]
Further reading
Further reading
- Buono P, Mancini FP, Izzo P, Salvatore F (1990). “Characterization of the transcription-initiation site and of the promoter region within the 5′ flanking region of the human aldolase C gene”. Eur. J. Biochem. 192 (3): 805–11. PMID 2209624.
- Rocchi M, Vitale E, Covone A; et al. (1989). “Assignment of human aldolase C gene to chromosome 17, region cen—-q21.1”. Hum. Genet. 82 (3): 279–82. PMID 2731939.
- Rottmann WH, Deselms KR, Niclas J; et al. (1987). “The complete amino acid sequence of the human aldolase C isozyme derived from genomic clones”. Biochimie. 69 (2): 137–45. PMID 3105602.
- Buono P, Paolella G, Mancini FP; et al. (1988). “The complete nucleotide sequence of the gene coding for the human aldolase C.”. Nucleic Acids Res. 16 (10): 4733. PMIDÂ 3267224.
- Tolan DR, Niclas J, Bruce BD, Lebo RV (1987). “Evolutionary implications of the human aldolase-A, -B, -C, and -pseudogene chromosome locations”. Am. J. Hum. Genet. 41 (5): 907–24. PMID 3674018.
- Penhoet E, Rajkumar T, Rutter WJ (1967). “Multiple forms of fructose diphosphate aldolase in mammalian tissues”. Proc. Natl. Acad. Sci. U.S.A. 56 (4): 1275–82. PMID 5230152.
- Andersson B, Wentland MA, Ricafrente JY; et al. (1996). “A “double adaptor” method for improved shotgun library construction”. Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Yu W, Andersson B, Worley KC; et al. (1997). “Large-scale concatenation cDNA sequencing”. Genome Res. 7 (4): 353–8. PMID 9110174.
- Kim JH, Lee S, Kim JH; et al. (2002). “Phospholipase D2 directly interacts with aldolase via Its PH domain”. Biochemistry. 41 (10): 3414–21. PMID 11876650.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Arakaki TL, Pezza JA, Cronin MA; et al. (2005). “Structure of human brain fructose 1,6-(bis)phosphate aldolase: linking isozyme structure with function”. Protein Sci. 13 (12): 3077–84. doi:10.1110/ps.04915904. PMID 15537755.
- Buono P, Barbieri O, Alfieri A; et al. (2005). “Diverse human aldolase C gene promoter regions are required to direct specific LacZ expression in the hippocampus and Purkinje cells of transgenic mice”. FEBS Lett. 578 (3): 337–44. doi:10.1016/j.febslet.2004.11.032. PMID 15589842.
- Kim SC, Sprung R, Chen Y; et al. (2006). “Substrate and functional diversity of lysine acetylation revealed by a proteomics survey”. Mol. Cell. 23 (4): 607–18. doi:10.1016/j.molcel.2006.06.026. PMID 16916647.