Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
AQP5
Introduction
Aquaporin-5 is a protein that in humans is encoded by the AQP5 gene.[1][2]
Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions [2]. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13.[2]
References
References
- ↑ Lee MD, Bhakta KY, Raina S, Yonescu R, Griffin CA, Copeland NG, Gilbert DJ, Jenkins NA, Preston GM, Agre P (Jun 1996). “The human Aquaporin-5 gene. Molecular characterization and chromosomal localization”. J Biol Chem. 271 (15): 8599–604. doi:10.1074/jbc.271.15.8599. PMID 8621489.
- ↑ 2.0 2.1 2.2 “Entrez Gene: AQP5 aquaporin 5”.
Further reading
Further reading
- Verkman AS (2003). “Role of aquaporin water channels in eye function”. Exp. Eye Res. 76 (2): 137–43. doi:10.1016/S0014-4835(02)00303-2. PMID 12565800.
- Ma T, Yang B, Umenishi F, Verkman AS (1997). “Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13”. Genomics. 43 (3): 387–9. doi:10.1006/geno.1997.4836. PMID 9268644.
- Smith JK, Siddiqui AA, Modica LA, et al. (1999). “Interferon-alpha upregulates gene expression of aquaporin-5 in human parotid glands“. J. Interferon Cytokine Res. 19 (8): 929–35. doi:10.1089/107999099313479. PMID 10476940.
- Kreda SM, Gynn MC, Fenstermacher DA, et al. (2001). “Expression and localization of epithelial aquaporins in the adult human lung”. Am. J. Respir. Cell Mol. Biol. 24 (3): 224–34. doi:10.1165/ajrcmb.24.3.4367. PMID 11245621.
- Gresz V, Kwon TH, Hurley PT, et al. (2001). “Identification and localization of aquaporin water channels in human salivary glands”. Am. J. Physiol. Gastrointest. Liver Physiol. 281 (1): G247–54. PMID 11408278.
- Nejsum LN, Kwon TH, Jensen UB, et al. (2002). “Functional requirement of aquaporin-5 in plasma membranes of sweat glands”. Proc. Natl. Acad. Sci. U.S.A. 99 (1): 511–6. doi:10.1073/pnas.012588099. PMC 117591. PMID 11773623.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Burghardt B, Elkaer ML, Kwon TH, et al. (2003). “Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas”. Gut. 52 (7): 1008–16. doi:10.1136/gut.52.7.1008. PMC 1773699. PMID 12801959.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). “Towards a proteome-scale map of the human protein-protein interaction network”. Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Chen Z, Wang X, Gao L, et al. (2006). “Regulation of MUC5AC mucin secretion by depletion of AQP5 in SPC-A1 cells”. Biochem. Biophys. Res. Commun. 342 (3): 775–81. doi:10.1016/j.bbrc.2006.01.103. PMID 16500622.
- Sidhaye VK, Güler AD, Schweitzer KS, et al. (2006). “Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditions”. Proc. Natl. Acad. Sci. U.S.A. 103 (12): 4747–52. doi:10.1073/pnas.0511211103. PMC 1450241. PMID 16537379.
- Pedersen PS, Braunstein TH, Jørgensen A, et al. (2007). “Stimulation of aquaporin-5 and transepithelial water permeability in human airway epithelium by hyperosmotic stress”. Pflügers Arch. 453 (6): 777–85. doi:10.1007/s00424-006-0157-3. PMID 17043812.
- Skowron-zwarg M, Boland S, Caruso N, et al. (2007). “Interleukin-13 interferes with CFTR and AQP5 expression and localization during human airway epithelial cell differentiation”. Exp. Cell Res. 313 (12): 2695–702. doi:10.1016/j.yexcr.2007.02.035. PMID 17553491.
External links
External links
- AQP5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human AQP5 genome location and AQP5 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.