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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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ARGLU1

Introduction

Arginine and glutamate-rich protein 1 is a protein that in humans is encoded by the ARGLU1 gene located at 13q33.3.[1]

The protein product of this gene has been proposed as a MED1-interacting protein required for estrogen-dependent gene transcription and breast cancer cell growth.[2]

The ARGLU1 gene expresses at least three distinct RNA splice isoforms – a fully spliced isoform coding for the protein, an isoform containing a retained intron that is detained in the nucleus, and an isoform containing an alternative exon that targets the transcript for nonsense mediated decay. Furthermore, ARGLU1 contains a long, highly evolutionarily conserved sequence known as an Ultraconserved Element (UCE) that is within the retained intron and overlaps the alternative exon. [3]

References

References

  1. ↑ “Entrez Gene: ARGLU1 arginine and glutamate rich 1”.
  2. ↑ Zhang D, Jiang P, Xu Q, Zhang X (May 2011). “Arginine and glutamate-rich 1 (ARGLU1) interacts with mediator subunit 1 (MED1) and is required for estrogen receptor-mediated gene transcription and breast cancer cell growth”. J. Biol. Chem. 286 (20): 17746–54. doi:10.1074/jbc.M110.206029. PMC 3093850. PMID 21454576.
  3. ↑ “An Ultraconserved Element (UCE) controls homeostatic splicing of ARGLU1 mRNA”. doi:10.1093/nar/gkw1140. PMC 5389617. PMID 27899669.
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