ARHGAP5

Rho GTPase-activating protein 5 is an enzyme that in humans is encoded by the ARHGAP5 gene.^[1]^[2]

Function

Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family that may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene.^[2]

Interactions

ARHGAP5 has been shown to interact with Rnd1,^[3] Rnd2,^[3] Rnd3^[3] and RHOA.^[3]

References

↑ Burbelo PD, Miyamoto S, Utani A, Brill S, Yamada KM, Hall A, Yamada Y (1995). “p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking”. J. Biol. Chem. 270 (52): 30919–26. doi:10.1074/jbc.270.52.30919. PMID 8537347.
↑ ^2.0 ^2.1 “Entrez Gene: ARHGAP5 Rho GTPase activating protein 5”.
↑ ^3.0 ^3.1 ^3.2 ^3.3 Wennerberg K, Forget MA, Ellerbroek SM, Arthur WT, Burridge K, Settleman J, Der CJ, Hansen SH (Jul 2003). “Rnd proteins function as RhoA antagonists by activating p190 RhoGAP”. Curr. Biol. 13 (13): 1106–15. doi:10.1016/S0960-9822(03)00418-4. PMID 12842009.

External links

Human ARHGAP5 genome location and ARHGAP5 gene details page in the UCSC Genome Browser.

Further reading

Ellis C, Moran M, McCormick F, Pawson T (1990). “Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases”. Nature. 343 (6256): 377–81. doi:10.1038/343377a0. PMID 1689011.
Foster R, Hu KQ, Shaywitz DA, Settleman J (1994). “p190 RhoGAP, the major RasGAP-associated protein, binds GTP directly”. Mol. Cell. Biol. 14 (11): 7173–81. PMC 359251. PMID 7935432.
McGlade J, Brunkhorst B, Anderson D, Mbamalu G, Settleman J, Dedhar S, Rozakis-Adcock M, Chen LB, Pawson T (1993). “The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion”. EMBO J. 12 (8): 3073–81. PMC 413572. PMID 8344248.
Bonaldo MF, Lennon G, Soares MB (1996). “Normalization and subtraction: two approaches to facilitate gene discovery”. Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Zrihan-Licht S, Fu Y, Settleman J, Schinkmann K, Shaw L, Keydar I, Avraham S, Avraham H (2000). “RAFTK/Pyk2 tyrosine kinase mediates the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion”. Oncogene. 19 (10): 1318–28. doi:10.1038/sj.onc.1203422. PMID 10713673.
Kulkarni SV, Gish G, van der Geer P, Henkemeyer M, Pawson T (2000). “Role of p120 Ras-GAP in directed cell movement”. J. Cell Biol. 149 (2): 457–70. doi:10.1083/jcb.149.2.457. PMC 2175152. PMID 10769036.
Chakravarty G, Roy D, Gonzales M, Gay J, Contreras A, Rosen JM (2000). “P190-B, a Rho-GTPase-activating protein, is differentially expressed in terminal end buds and breast cancer”. Cell Growth Differ. 11 (7): 343–54. PMID 10939588.
Shiota M, Tanihiro T, Nakagawa Y, Aoki N, Ishida N, Miyazaki K, Ullrich A, Miyazaki H (2003). “Protein tyrosine phosphatase PTP20 induces actin cytoskeleton reorganization by dephosphorylating p190 RhoGAP in rat ovarian granulosa cells stimulated with follicle-stimulating hormone”. Mol. Endocrinol. 17 (4): 534–49. doi:10.1210/me.2002-0187. PMID 12554790.
Wennerberg K, Forget MA, Ellerbroek SM, Arthur WT, Burridge K, Settleman J, Der CJ, Hansen SH (2003). “Rnd proteins function as RhoA antagonists by activating p190 RhoGAP”. Curr. Biol. 13 (13): 1106–15. doi:10.1016/S0960-9822(03)00418-4. PMID 12842009.
Su L, Agati JM, Parsons SJ (2003). “p190RhoGAP is cell cycle regulated and affects cytokinesis”. J. Cell Biol. 163 (3): 571–82. doi:10.1083/jcb.200308007. PMC 2173658. PMID 14610059.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). “Functional proteomics mapping of a human signaling pathway”. Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Blanchetot C, Chagnon M, Dubé N, Hallé M, Tremblay ML (2005). “Substrate-trapping techniques in the identification of cellular PTP targets”. Methods. 35 (1): 44–53. doi:10.1016/j.ymeth.2004.07.007. PMID 15588985.
Vargo-Gogola T, Heckman BM, Gunther EJ, Chodosh LA, Rosen JM (2006). “P190-B Rho GTPase-activating protein overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland”. Mol. Endocrinol. 20 (6): 1391–405. doi:10.1210/me.2005-0426. PMID 16469769.
Zhan X, Desiderio DM (2006). “Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry”. Anal. Biochem. 354 (2): 279–89. doi:10.1016/j.ab.2006.05.024. PMID 16777052.

[pmid8537347-1] Burbelo PD, Miyamoto S, Utani A, Brill S, Yamada KM, Hall A, Yamada Y (1995). “p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking”. J. Biol. Chem. 270 (52): 30919–26. doi:10.1074/jbc.270.52.30919. PMID 8537347.

[entrez-2] 2.0 ^2.1 “Entrez Gene: ARHGAP5 Rho GTPase activating protein 5”.

[pmid12842009-3] 3.0 ^3.1 ^3.2 ^3.3 Wennerberg K, Forget MA, Ellerbroek SM, Arthur WT, Burridge K, Settleman J, Der CJ, Hansen SH (Jul 2003). “Rnd proteins function as RhoA antagonists by activating p190 RhoGAP”. Curr. Biol. 13 (13): 1106–15. doi:10.1016/S0960-9822(03)00418-4. PMID 12842009.

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